Neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and others, cause neuronal degradation, resulting in progressive brain function deterioration. Although our understanding of neurodegenerative disease mechanisms is still in its relative infancy, scientists pursue understanding of neurodegenerative disease pathogenesis and development that paves identification of new potential therapeutic and treatment approaches. Neurodegenerative […]
Tagged: Parkinson’s Disease
Neurodegenerative Diseases: In Pursuit of a Cure
December 3rd, 2020 | Parkinson’s DiseaseExperience in rare disease and enzyme replacement treatment may help clinical plans for Parkinson’s disease: Lysosomal Dysfunction – A Parkinson’s-Gaucher Link?
January 17th, 2020 | Parkinson’s DiseaseWorldwide, over 4,000 patients with Gaucher disease have received enzyme replacement treatment (ERT), which is safe and well tolerated. Gaucher disease is a rare disease caused by mutations in GBA1. GBA1 mutations drive extensive accumulation of glucosylceramide (GC) in immune cells in the spleen, liver, lung and bone marrow. Extensive GC storage induces complement-activating IgG […]