Translational Research

Epigenetic Signature – Case Study

Our senior advisor, Dr. Claudio Carini, led the translational medicine department at major pharmaceutical companies.

The Translational Medicine and Biomarkers Program Consultation will:

  • Accelerate product development and approval.
  • Increase the success of the clinical trials.
  • Meet FDA and EMA high priority call for innovation in clinical research.

 

Case Study

Biomarker Signature in Rheumatoid Arthritis MTX Responders

PROJECT: One of the most important questions in treating physician’s mind is how to know which patient will respond to which drug in a given disease.

SOLUTION: Retrospective study in patients with early rheumatoid arthritis to identify a signature able to differentiate responder from no responder to methotrexate. Such a signature would allow for early treatment with biologics in patients not able to respond to first line treatment. Data showed the first signature able to predict responders from no-responders in RA patients. This work is a milestone in precision medicine for RA.

Results were published in J Transl Med. doi: [10.1186/s12967-018-1387-9]

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